Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) is a water soluble, cytocompatible, type I photoinitiator used in the polymerization of hydrogels or other water-soluble polymeric materials. LAP is preferred for biological applications over Irgacure 2959 due to its increased water solubility, increased polymerization at 365 nm, and the capacity of polymerization at 405 nm (visible light). These properties allow for a reduction of the required concentration for crosslinking and the use of longer wavelengths, which have been shown to reduce cytotoxicity and increase cell viability.
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